Ronaldo suffered further ankle damage against Hungary in October
Portugal winger Cristiano Ronaldo has been ruled out of his country's 2010 World Cup play-off ties against Bosnia-Hercegovina on 14 and 18 November.
Ronaldo travelled to his homeland to have his ankle injury assessed, despite Spanish club Real Madrid claiming their player would not be fit enough to play.
"Cristiano was in Lisbon on Tuesday," said Portugal's football federation.
"The player is not in good enough physical condition to train with the squad ahead of the play-offs."
The Portuguese FA said they wished Ronaldo a "good and rapid recovery" from an injury he picked up playing for Madrid in a Champions League game against Marseille on 30 September.
He has not played in seven games for the Spanish club since but did figure for Portugal in a World Cup qualifier against Hungary on 10 October when he aggravated the problem.
Portugal, World Cup semi-finalists in 2006, play Bosnia-Hercegovina in Lisbon and then Zenica four days later, with the aggregate winners qualifying for the 2010 finals in South Africa.